The coming wave is defined by two core technologies: artificial in-telligence (AI) and synthetic biology. Together they will usher in a newdawn for humanity, creating wealth and surplus unlike anything everseen. And yet their rapid proliferation also threatens to empower a di-verse array of bad actors to unleash disruption, instability, and evencatastrophe on an unimaginable scale. This wave creates an immensechallenge that will define the twenty-first century: our future both de-pends on these technologies and is imperiled by them. - P7